尤明：现为威斯康星医学院副院长、II级教授和癌症研究中心所长。本科毕业于北京大学医学部，在俄亥俄州洲大学医学院获病理学博士学位。尤明教授是美国国家癌症研究所（NCI）癌症易感性及化学预防智囊团成员和化学预防药物发展研究集团审查小组主席，美国国家卫生研究所（NIH）化疗/饮食预防和化学病理学研究组成员。还担任世界著名期刊Cancer Research和Cancer Prevention副主编，PLoS One学术主编，Carcinogenesis、Translational Oncogenomics和Application of Clinical Genetics等世界著名期刊编委。研究领域为肿瘤学，研究方向为肺癌的发病机制及其化学预防治疗研究。主持评审NIH等科研课题40余项，在Cell 等世界顶尖杂志上发表SCI 论文280余篇，在肺癌的化学预防研究中取得了杰出成就。

研究方向

● 个体化用药

● 肺癌的化学预防

● 啮齿动物和人类肺癌的易感基因研究

● 肺癌的分子发病机制

发表论文

pan J, Zhang Q, Li K, Liu Q, Wang Y, You M*. Chemoprevention of lungsquamous cell carcinoma by ginseng. Cancer Prev Res (Phila). 2013Jun;6(6):530-9.

Xiong D, Li G, Li K, Xu Q, Pan Z, Ding F,Vedell P, Liu P, Cui P, Hua X, Jiang H, Yin Y, Zhu Z, Li X, Zhang B, Ma D, WangY, You M*. Exome sequencingidentifies MXRA5 as a novel cancer gene frequently mutated in non-small celllung carcinoma from Chinese patients. Carcinogenesis. 2012 Sep;33(9):1797-805.

Liu P, Morrison C, Wang L, Xiong D, Vedell P,Cui P, Hua X, Ding F, Lu Y, James M, Ebben JD, Xu H, Adjei AA, Head K, AndraeJW, Tschannen MR, jacob H,Pan J, Zhang Q, Van den Bergh F, Xiao H, Lo KC, PatelJ, Richmond T, Watt MA, Albert T, Selzer R, Anderson M, Wang J, Wang Y, StarnesS, Yang P, You M*. Identification ofsomatic mutations in non-small cell lung carcinomas using whole-exomesequencing. Carcinogenesis. 2012 Jul;33(7):1270-6.

Zhang Q, pan J, Wang Y, Lubet R, You M*. Beetroot 红色 (betanin) inhibitsvinyl carbamate- and benzo(a)pyrene-induced lung tumorigenesis throughapoptosis. 摩尔 CarcinOrigen 2013 Sep;52(9):686-91.

Zhang Q, Pan J, North PE, Yang S, Lubet RA,Wang Y, You M*. Aerosolized3-bromopyruvate inhibits lung tumorigenesis without causing liver toxicityCancer Prev Res (Phila). 2012 May;5(5):717-25.

Lu Y, Govindan R, Wang L, Liu PY, Goodgame B,Wen W, Sezhiyan A, Pfeifer J, Li YF, Hua X, Wang Y, Yang P, You M*. MicroRNA profiling andprediction of recurrence/relapse-free survival in stage I lung cancer.Carcinogenesis. 2012 May;33(5):1046-54.

Liu P, Lu Y, Liu H, Wen W, Jia D, Wang Y, You M*. Genome-wide association andfine mapping of genetic loci predisposing to colon carcinogenesis in mice. MolCancer Res. 2012 Jan;10(1):66-74.

Wang Y, Yao R, Gao S, Wen W, Du Y, Szabo E,Hu M, Lubet RA, You M*.Chemopreventive effect of a mixture of Chinese Herbs (antitumor B) on chemicallyinduced oral carcinogenesis. 摩尔 CarcinOrigen 2013 Jan;52(1):49-56.

Lu Y, Liu P, Van den Bergh F, Zellmer V, JamesM, Wen W, Grubbs CJ, Lubet RA, You M*.Modulation of gene expression and cell-cycle signaling pathways by the EGFRinhibitor gefitinib (Iressa) in rat urinary bladder cancer. Cancer Prev Res(Phila). 2012 Feb;5(2):248-59.

Govindan R, Ding L, Griffith M, Subramanian J,Dees ND, Kanchi KL, Maher CA, Fulton R, Fulton L, Wallis J, Chen K, Walker J,McDonald S, Bose R, Ornitz D,Xiong D, You M, Dooling DJ, Watson M, Mardis ER, Wilson RK. Genomic landscape ofnon-small cell lung cancer in smokers and never-smokers. Cell. 2012 Sep14;150(6):1121-34.