金京波，男，1974年3月出生于吉林省图们市，博士，研究员，博士生导师。1996年在中国农业大学获得学士，1999年和2002年分别在韩国庆尚国立大学获得硕士和博士学位。2002年3月至2008年11月，金京波先后在韩国浦项工业大学和普渡大学进行博士后工作。现任中国科学院植物研究所研究员及课题组组长。2008年，金京波入选“百人计划”。至今，他已发表SCI收录刊物论文34篇，其中包括两篇通讯（或共同通讯）作者论文和五篇第一（或共同第一）作者论文。目前，金京波正在指导5名博士生和4名硕士生。

1974年3月出生，吉林省人。

中国科学院植物研究所植物分子生理学重点实验室 研究组长，研究员，中科院“百人计划”入选者。

1992.07-1996.06 中国农业大学 学士 农业应用化学；

1997.03-1999.02 韩国庆尚国立大学 硕士 分子生物学；

1999.03-2002.02 韩国庆尚国立大学 博士 分子生物学；

2002.03-2004.05 韩国浦项工业大学 博士后；

2004.06-2008.11 普渡大学 博士后；

2008.11-至今 中科院中国科学院植物研究所 研究员。

融合遗传、生化、分子和细胞生物学的方法，研究sumoylation和组蛋白去甲基化在环境胁迫感应和植物发育过程的调控机制。

1. 在动物，蛋白质加SUMO化调控免疫系统，细胞分裂和分化，脱氧核糖核酸修饰，epigenetic基因表达，细胞核与细胞质物质移动，信号传导等。我要阐明sumoylation调控植物抗逆反应和发育程序机制，包括但不限于：(1)筛选及研究SIZ1和SUMO相互作用分子；(2)发现及研究SIZ1的下游基因；(3)筛选及研究siz1suppressor 突变体；(4) 研究SIZ1自身调控的机制。

2. 组蛋白甲基化(Histone methylation) 影响基因表达和染色质状况，调节多细胞生物的激素和胁迫反应及发育程序。最近的科学研究结果发现组蛋白去甲基化酶(histone demethylase)对植物的开花时期和发育起重要的调控作用。除此之外，好多抗逆相关基因的表达与组蛋白甲基化有密切联系，但对其调节机制并不清楚。我的远程目标是阐明植物组蛋白去甲基化酶的功能及作用机制。(1)研究SUMO modification调节FLD (一个组蛋白去甲基化酶) 蛋白质活性的机制；(2)建立完善抗逆基因表达和组蛋白去甲基化的相关性。(3) 发现新的组蛋白去甲基化酶并研究它们的功能和作用机制。

3. 利用所得到的研究结果，结合已有的技术基础，开发抗逆及符合不同生长环境的高产量农作物或能源作物。

1. Jin, J.B., and Hasegawa, P.M. 2008. Flowering 时间 regulation by the SUMO E3 ligase SIZ1. Plant Signaling \u0026 Behavior In press.

2. Jin, J.B., Jin, Y.H., Lee, J., Miura, K., yoo, C.Y., Kim, W.Y., Oosten, M.V., Hyun, Y., Somers, D.E., Lee, I., Yun, D.J., BRESSAN, R.A., and Hasegawa, P.M. 2008. The SUMO E3 ligase, AtSIZ1, regulates flowering by controlling a salicylic acid-mediated floral promotion pathway and through affects on FLC chromatin structure. Plant J. 53:530-540.

3. Kim, J.I., Sharkhuu, A., Jin, J.B., Li, P., Jeong, J.C., Baek, D., Lee, S.Y., Blakeslee, J.J., Murphy, A.S., Bohnert, H.J., Hasegawa, P.M., Yun, D.J., Bressan, R.A. 2007. yucca6, a Dominant Mutation in Arabidopsis, Affects Auxin Accumulation and Auxin-related Phenotypes. Plant Physiol. 145:722-35.

4. Miura, K., Jin, J.B., Hasegawa, P.M. 2007. Sumoylation, a post-translational regulatory process in plants. Curr. Opin. Plant Biol. 10:495-502.

5. Inan, G., Goto, F., Jin, J.B., Rosado, A., Koiwa, H., Shi, H., Hasegawa, P.M., Bressan, R.A., Maggio, A., Li, X. 2007. Isolation and characterization of shs1, a sugar-hypersensitive and ABA-insensitive mutant with multiple stress responses. Plant 摩尔 Biol.65:295-309.

6. Miura, K., Jin, J.B., Lee, J., Yoo, C.Y., Stirm, V., Miura, T., Yun, D.-J., Bressan, R.A., and Hasegawa, P.M. 2007. Low 温度 induces SIZ1-mediated sumoylation of ICE1 that controls CBF3/DREB1A expression and freezing tolerance. Plant Cell 19: 1403-14.

7. Lee, J., Nam, J., Park, H.C., Na, G., Miura, K., Jin, J.B., Yoo, C.Y., Baek, D., Kim, D.H., Jeong, J.C., Kim, D., Lee, S.Y., Salt, D.E., Mengiste, T., Gong, Q., Ma, S., Bohnert, H.J., Kwak, S.-S., Bressan, R.A., Hasegawa, P.M. and Yun, 丹尼斯·约翰逊 2007. Salicylic acid-mediated innate immunity in Arabidopsis is regulated by SIZ1 SUMO E3 ligase. Plant J. 49: 79-90.

8. Lee, M.H., Lee, S.H., Kim, H., Jin, J.B., Kim, D.H., Hwang, I. 2006. A WD40 repeat protein, Arabidopsis Sec13 homolog 1, may play a role in vacuolar trafficking by controlling the membrane association of AtDRP2A. 摩尔 Cells 22:.210-9.

9. Yoo, C.Y., Miura, K., Jin, J.B., Lee, J., Park, H.C., Salt, D.E., Yun, D.J., Bressan, R.A., Hasegawa, P.M. 2006. SIZ1 SUMO E3 Ligase Facilitates Basal Thermotolerance in Arabidopsis Independent of Salicylic Acid. Plant Physiol. 142: 1548-58.

10.Kang, C.H., Jung, W.Y., Kang, Y.H., Kim, J.Y., Kim, D.G., Jeong, J.C., Baek, D.W., Jin, J.B., Chung, W.S., Mengiste, T., Koiwa, H., Bahk, J.D., Lee, S.Y., Nam, J.S., Yun, D.J. and Cho, M.J. 2005. AtBAG6, a novel calmodulin-binding protein, induces programmed cell 死亡 in 酵母浸膏 and plants. Cell Death Differ. 13: 84-95 .

11.Miura, K., Rus, A., Sharkhuu, A., Yokoi, S., Karthikeyan, A.S., Raghothama, 千克, Baek, D., Koo, Y.D., Jin,

J.B., Bressan, 类风湿性关节炎, Yun, D.J., and Hasegawa, P.M. 2005. The Arabidopsis SUMO E3 ligase SIZ1 controls

磷酸盐 deficiency responses. Proc. Natl. Acad. Sci. 102:7760-7765.

12.Narasimhan, M.L.*, Coca, A.*, Jin, J.B., Yamauchi, T., Ito, Y., Kadowaki, T., Kim, K.K., Pardo, Jackie McLean, Damsz,

B., Hasegawa, P.M., Yun, D.J. and Bressan, 类风湿性关节炎 2005. Osmotin is a homolog of mammalian adiponectin and

controls apoptosis in yeast through a homolog of mammalian adiponectin 捕手 Molecular Cell 17: 171-180.

(*These authors contributed equally to this work.) .

13.Jin. J.B., Bae, H.-J., Kim, D.H., Lee, Y.J., Tse, Y.C., Kim, Super Junior, Jiang, L., Goh, C.-H., Jin, Y.H. and Hwang, I.

2003. New Arabidopsis dynamin-like proteins, ADL1E and ADL1C, play a critical role in mitochondrial

Morphogenesis. Plant Cell 15: 2357-2369.

14.Kim, C.Y.*, Koo, Y.D.*, Jin, J.B.*, Moon, B.C., Kang, C.H., Kim, S.T., Park, B.O., Lee, S.Y., Kim, M.L.,

Hwang, I., Kang, K.Y., Bahk, J.D., Lee, S.Y. and Cho, M.J. 2003. Rice C2-domain proteins are induced and

translocated to the 等离子体 membrane in response to fungal 激发子 Biochemistry 42: 11625-11633. (*These

authors contributed equally to this work.) .

15.Lee, K.H., Kim, S.J., Lee, Y.J., Jin, J.B. and Hwang, I. 2003. The M domain of atToc159 plays an essential role in the import of proteins into chloroplasts and chloroplast biogenesis. J. Biol. Chem. 278: 36794-36805.

16.Lee, M.H., Min, M.K., Lee, Y.J., Jin, J.B., Shin, D.H., Kim, D.H., Lee, K.H. and Hwang, I. 2002. ADP-

ribosylation factor 1 of Arabidopsis plays a critical role in intracellular trafficking and maintenance of endoplasmic

reticulum morphology in Arabidopsis. Plant Physiol. 129: 1507-1520.

17.Lee, S.H., Jin, J.B., Song, J., Min, M.K., Park, D.S., Kim, Y.W. and Hwang, I. 2002. The intermolecular

interaction between the PH domain and the C-terminal domain of Arabidopsis dynamin-like 6 determines lipid

binding specificity. J. Biol. Chem. 277: 31842-31849.

18.Jin, J.B., Kim, Y.A., Kim, Super Junior, Lee, S.H., Kim, D.H., Cheong, G.W. and Hwang, I. 2001. A new dynamin-like

protein, ADL6, is involved in trafficking from the trans-Golgi network to the central vacuole in Arabidopsis. Plant

细胞 13: 1511-1526.

19.Kim, D.H., Eu, Y.J., Yoo, C.M., Kim, Y.W., Pih, KT Rolster, Jin, J.B., Kim, Super Junior, Stenmark, H. and Hwang, I. 2001.

Trafficking of phosphatidylinositol 3-磷酸盐 from the trans-Golgi network to the lumen of the central vacuole

in plant cells. Plant Cell 13: 287-301.

20.Piao, H.L, Pih, KT Rolster, Lim, J.H., Kang, S.G., Jin, J.B., Kim, S.H. and Hwang, I. 1999. An Arabidopsis

GSK3/shaggy-like gene that complements yeast salt 应力sensitive mutants is induced by NaCl and abscisic

acid. Plant Physiol. 119: 1527-34.

21.Pih, KT Rolster, Kabilan, V., Lim, J.H., Kang, S.G., Piao, H.L, Jin, J.B. and Hwang, I. 1999. Characterization of two

new channel protein genes in Arabidopsis. 摩尔 Cells 9: 84-90.

22.Kang, S.G., Jin, J.B., Piao, H.L., Pih, KT Rolster, Jang, H.J., Lim, J.H. and Hwang, I. 1998. Molecular cloning of an

Arabidopsis cDNA encoding a dynamin-like protein that is localized to plastids. Plant 摩尔 Biol. 38: 437-47.

23.Jang, H.J., Pih, KT Rolster, Kang, S.G., Lim, J.H., Jin, J.B., Piao, H.L and Hwang, I. 1998. Molecular cloning of a

novel ca(clo)2+-binding protein that is induced by NaCl 应力 Plant 摩尔 Biol. 37: 839-47.