巢晖(Hui Chao),男,1970年3月出生,籍贯湖南罗,理学博士,中山大学教授,博士生导师。
学术简历
学士(1988-1992):
湖南科技大学化学化工学院;
博士(1997-2000):中山大学
化学与化学工程学院;
访问学者 (2000-2003):
香港科技大学化学系;
博士后(2004-2005):美国Texas A\u0026M大学化学系;
讲师(2000-2002)、副教授(2002-2007):中山大学化学与化学工程学院;
教授(2008-至今):中山大学化学与化学工程学院;
2002年6月被遴选为
中山大学无机化学专业/化学生物学专业硕士生导师;
2005年-至今:中山大学光电材料与技术国家重点实验室固定研究人员。
2017年-至今:
湖南科技大学理论有机化学与功能分子教育部重点实验室“湘江学者计划”特聘教授。
科研方向
1.金属
配位化合物与
脱氧核糖核酸/
核糖核酸相互作用研究(包括DNA/RNA结构识别、光断裂及
转录抑制)。
2.配合物超分子体系光电转换和光致电子与能量转移调控研究。
3.多吡配合物为基元的分子器件设计及其光电性能应用。
学术成绩
1.已发表学术论文40多篇, 其中SCI收录论文30篇。
2.现主持国家自然科学基金1项,参加国家、省自然科学基金及国家重点实验室开放课题基金5项。
(1) 国家自然科学基金项目(2002.1-2004.12):钌多吡啶
配位化合物为基元的某些分子器件设计及其应用,项目负责人。
(2) 国家自然科学基金项目(2001.1-2003.12):金属配合物研究
脱氧核糖核酸的结构、功能及作用机制,主要成员。
(3) 国家自然科学基金重点项目(2003.1-2005.12):金属配合物、生物大分子
蛋白质和DNA的相互作用,主要成员。
(4)
广东省自然科学项目(2003.1-2005.12):抗癌性多吡啶类配合物量子化学研究、
计算机模拟及合成, 主要成员。
(5)
配位化合物国家重点实验室(南京大学)开放课题基金(2002.4-2004.3):位点和顺序专一
核糖核酸和DNA切割剂合成及其作用机制,主要成员。
(6) 生命有机化学国家重点实验室(中科院上海有机化学研究所)开放课题基金(2000.7-2003.6):
核酸的结构与功能关系中的重大化学问题的研究,主要成员。
教学科研成果
“金属酶模型化合物的结构、生物功能、作用机制之间规律性”,中国高校
自然科学奖二等奖,2000年(排名第九)。
主要论著
(均为SCI收录):
1. Feng Gao,Hui Chao*, Feng Zhou, Xin Chen, Yuan-Fang Wei, Kang-Cheng Zheng, Liang-Nian Ji*, “Synthesis,
脱氧核糖核酸 binding and topoisomerase II inhibition activities of ruthenium(II) polypyridyl complex containing 11-aminopteridino[6,7-f][1,10]phenanthrolin-13(12H)-one”,J. Inorg. Biochem. ,2008, in press.
2. Feng Gao,Hui Chao*, Liang-Nian Ji*,“
脱氧核糖核酸Binding, Photocleavge and Topoisomerase Inhibiting of Functionalized Ruthenium(II) Polypyridyl Complexes”,Chemistry \u0026 Biodiversity, 2008, in press. (Review)
3. Hui-Juan Yu,Hui Chao*, Long Jiang,
路易威登Ying Li, Shu-Mei Huang and Liang-Nian Ji*, “Single oxygen-mediated
脱氧核糖核酸 photocleavage of a di-bithiazolyl ruthenium(II) complex [Ru(btz)2(dppz)]2+”,Inorg. Chem. Commun. ,2008, in press.
4. Feng Gao,Hui Chao*, Yuan-Fang Wei, Yi-Xian Yuan, Bin Peng, Xin Chen, Kang-Cheng Zheng and Liang-Nian Ji*, “Synthesis,
脱氧核糖核酸Binding and Photocleavage Studies of Ruthenium(II) Complexes [Ru(phen)2(ppd)]2+ and [Ru(phen)(ppd)2]2+ (ppd = Pteridino[6,7-f][1,10]- phenanthroline-1,13(10H,12H)-dione, phen = 1,10-Phenanthroline)”,Helv. Chim. Acta, 2008, in press.
5. F. Albert Cotton,Hui Chao*, Zhong Li, Carlos A. Murillo, Qingsheng Wang, “Effect of axial
120-12-7 ligands on the luminescence of trinickel molecular wires”,J. Organomet. Chem., 2008, in press.
6.巢晖*,高峰,
计亮年*,“钌(II)多
吡啶配位化合物与
脱氧核糖核酸相互作用研究”,化学进展,2007,19(12),1844-1851。 (化学生物学专辑,Review)
7. Feng Gao,Hui Chao*, Jin-Quan Wang, Yi-Xian Yuan, Bin Sun, Yuan-Fang Wei, Bin Peng and Liang-Nian Ji*, “Targeting topoisomerase II with the chiral DNA-intercalating ruthenium(II) polypyridyl complexes”,J. Biol. Inorg. Chem., 2007, 12, 1015-1027.
8. Bin
peng,Hui Chao*, Bin Sun, Hong Li, Feng Gao and Liang-Nian Ji*, “Syntheses,
脱氧核糖核酸binding and photocleavage studies of cobalt(III) mixed-polypyridyl complexes: [Co(phen)2(dpta)]3+ and [Co(phen)2(amtp)]3+”,J. Inorg. Biochem. ,2007, 101, 404-411.
9. Feng Gao,Hui Chao*, Feng Zhou, Bin Peng, Liang-Nian Ji*, “pH responsive “off-on-off” luminescent switch of a novel ruthenium(II) complex [Ru(bpy)2(pipi
PH2)]2+”,Inorg. Chem. Commun.,2007, 10, 170-173.
10. Feng Gao,Hui Chao*, Feng Zhou, Lian-Cai Xu, Kang-Cheng Zheng, Liang-Nian Ji*,“Synthesis, Characterization, and
脱氧核糖核酸Binding Properties of the Chiral Ruthenium(II) Complexes Δ- and Λ-[Ru(bpy)2(dmppd)]2+ (dmppd = 10,12-Dimethylpteridino- [6,7-f][1,10]phenanthroline-11,13(10H,12H)-dione; bpy = 2,2’-Bipyridine)”,Helv. Chim. Acta, 2007, 90, 36-51.
11. F. Albert Cotton,Hui Chao*, Carlos A. Murillo* and Qingsheng Wang, “A trimetal chain cocooned by two heptadentate polypyridylamide ligands”,Dalton Trans. ,2006, 5416-5422.
12. Feng Gao,Hui Chao*, Feng Zhou, Yi-Xian Yuan, Bin Peng and Liang-Nian Ji*, “
脱氧核糖核酸 interactions of a functionalized ruthenium(II) mixed-polypyridyl complex [Ru(bpy)2ppd]2+”,J. Inorg. Biochem.,2006, 100, 1487-1494.
13.
YunJun Liu,Hui Chao*, Yi-Xian Yuan, Hui-Juan Yu and Liang-Nian Ji*,“Ruthenium(II) mixed-ligand complexes containing 2-(6-methyl-3-chromonyl)imidazo- [4,5-f][1,10]phenanthroline: synthesis,
脱氧核糖核酸binding and photocleavage studies”,Inorg. Chim. Acta, 2006, 359, 3807-3814.
14.Hui Chao, Liang-Nian Ji, “Chapter 11. Cobalt complexes as potential pharmaceutical agents”, in Metallotherapeutic Drugs and Metal-Based Diagnostic Agents: The Use of Metals in Medicine, Eds. Marcel Gielen and Edward R. T. Tiekink, May, 2005, John Wiley \u0026 Sons Ltd (ISBN: 0-470-86403-6). (Book Chapter)
15.Hui Chao*, Lian-Nian Ji, “
脱氧核糖核酸 interactions with Ru(II) polypyridine complexes containing asymmetric ligands”,Bioinorganic
化学 and Application, 2005, 3, 15-28.(Review)
16.
YunJun Liu,Hui Chao*, Jun-Hua Yao, Li-Feng Tan, Yi-Xian Yuan, Liang-Nian Ji, “Ruthenium(II) complexes containing asymmetric 2-(pyrazin-2-yl)naphthoimidazole: syntheses, characterization,
脱氧核糖核酸binding and photocleavage studies”,Inorg. Chim. Acta, 2005, 358, 1904-1910.
17. Li-Feng Tan,Hui Chao*,
YunJun Liu, Hong Li, Bin Sun, Liang-Nian Ji*, “DNA-binding and photocleavage studies of [Ru(phen)2(NMIP)]2+”,Inorg. Chim. Acta, 2005, 358, 2191-2198.
18. Yun-Jun Liu,Hui Chao*, Li-Feng Tan, Yi-Xian Yuan, Wei Wei, Liang-Nian Ji*. “Interaction of polypyridyl ruthenium(II) complex containing asymmetric ligand with
脱氧核糖核酸”.J. Inorg. Biochem. ,2005, 99, 530-537.
19. Li-Feng Tan,Hui Chao*, Hong Li,
YunJun Liu, Bin Sun, Wei Wei, Liang-Nian Ji*. “Synthesis, characterization, DNA-binding and photocleavage studies of [Ru(bpy)2(PPIP)]2+ and [Ru(phen)2(PPIP)]2+”.J. Inorg. Biochem. ,2005, 99, 513-520.
20.
YunJun Liu,Hui Chao*, Jun-Hua Yao, Hong Li, Yi-Xian Yuan, Liang-Nian Ji*. “Synthesis, characterization and
脱氧核糖核酸 interaction studies of [Ru(bpy)2(CMIP)]2+ and [Ru(phen)2(CMIP)]2+ (CMIP = 2-(3-chromonyl)imidazo[4,5-f][1,10]-phenanthroline)”.Helv. Chim. Acta, 2004, 87, 3119-3130.
21. Xiang-Li Wang,Hui Chao*, Hong Li, Xian-Lan Hong,
YunJun Liu, Li-Feng Tan, Liang-Nian Ji*. “
脱氧核糖核酸 interactions of cobalt(III) mixed-polypyridyl complexes containing asymmetric ligands.”J. Inorg. Biochem. ,2004, 6, 1143-1150.
22. Xiang-Li Wang,Hui Chao*, Hong Li, Xian-Lan Hong, Liang-Nian Ji*, Xiao-Yuan Li*. “Synthesis, crystal structure and
脱氧核糖核酸 cleavage activities of copper(II) complexes with asymmetric tridentate ligands.”, ,2004, 98, 423-429.