田仕凯，男，博士，中国科学技术大学教授、博士生导师，2005年“百人计划”入选者。

1989.09 - 1993.07，兰州大学化学系，有机化学，理学学士

1993.09 - 1996.07，中国科学院上海有机化学研究所，有机合成化学，理学硕士

1996.09 - 1998.12，中国科学院上海有机化学研究所，有机合成化学，理学博士

1999.02 - 2002.04，美国Brandeis大学化学系，不对称催化，博士后

2002.04 - 2005.08，美国Vertex制药公司，药物化学，研究员

2005.09 - 现在，中国科学技术大学化学与材料科学学院，有机化学系，教授

新反应的发现及应用：1）设计与发展新型多组分反应，从而可快速有效地构筑复杂有机化合物，以便进行药物、有机催化剂、金属配体和其他功能分子的活性筛选和结构优化。2）以设计绿色催化剂为研究重点，发展具有广泛合成应用价值和对环境友好的催化反应。3）以应用和发展新型有机合成反应为出发点，高效率地合成生物活性天然产物。

新药的设计与合成：借助高效有机合成反应和高通量活性筛选技术，发现药物先导化合物，进行结构优化来提高其各方面的药物性质。

1. “Asymmetric Organic Catalysis with Modified cinchonaalkaloids” Shi-Kai Tian, Yonggang Chen, Jianfeng Hang, Liang Tang, Paul MaDaid, and Li Deng, Acc. Chem. Res. 2004, 37, 621-631.

2. “Catalytic Asymmetric Cyanosilylation of Ketones with Chiral Lewis Base” Shi-Kai Tian, Ran Hong and Li Deng, J. Am. Chem. Soc. 2003, 125, 9900-9901.

3. “Asymmetric Synthesis of a-Amino Acids via Cinchona Alkaloid-Catalyzed Kinetic Resolution of UreTHANEProtected a-Amino Acid N-Carboxyanhydrides” Jianfeng Hang, Shi-Kai Tian, Liang Tang, and Li Deng, J. Am. Chem. Soc. 2001, 123, 12696-12697.

4. “A Highly Enantioseletive Chiral Lewis Base-Catalyzed Asymmetric Cyanation of Ketones” Shi-Kai Tian and Li Deng, J. Am. Chem. Soc. 2001, 123, 6195-6196.

5. “A Formal Catalytic Asymmetric Synthesis of (+)-Biotin with Modified Cinchona Alkaloids” Chulho Choi, Shi-Kai Tian, and Li Deng, Synthesis 2001, 1737-1741.

6. “A Highly Enantioseletive Catalytic Desymmetrization of Cyclic Anhydrides with Modified Cinchona Alkaloids” Yonggang Chen, Shi-Kai Tian, and Li Deng, J. Am. Chem. Soc. 2000, 122, 9542-9543.

7. “A Facile Route to Bulladecin-Type Acetogenins?Total Synthesis of Asimilobin and Correction of the Configuration of Its Tetrahydrofuran Segment” Zhi-Min Wang, Shi-Kai Tian, and Min Shi, Eur. J. Org. Chem. 2000, 349-356.

8. “道达尔公司 Synthsis of Gigantetrocin A” Zhi-Min Wang, Shi-Kai Tian, and Min Shi, Chirality 2000, 12, 581-589.

9. “Diaminotriazoles Useful as Inhibitors of Protein Kinases” Albert C. Pierce, Michael Arnost, Robert J. Davies, Cornelia J. Forster, Vincent Galullo, Ronald Grey, Mark Ledeboer, Shi-Kai Tian, Jingwang Xu, Hayley Binch, Brian Ledford, David Messersmith, Suganthi Nanthakumar, Andrew Jayaraj, 2004, WO 2004/046120 A2

10. “Catalytic Asymmetric Cyanosilylation of Ketones, Aldehydes, Thioketones, Imines and Hydrazones” Li Deng and Shi-Kai Tian, 2003, WO 03/68714.

11. “Highly Enantioseletive Catalytic Desymmetrization of Cyclic meso Anhydrides with Modified Cinchona Alkaloids” Li Deng, Yonggang Chen, and ShiKai Tian, 2001, WO 01/74741.