丁建平 男 1982年1月南京大学获理学学士学位；1984年10月中山大学获理学硕士学位；1987年10月复旦大学获理学博士学位。1987年11月至1989年6月，中国科学院上海硅酸盐研究所博士后。1989年7月至1991年8月，德国柏林自由大学结晶学研究所洪堡基金会奖研金学者。1991年9月至2001年1月，美国新泽西州罗格斯大学，先后任化学与化学生物学系研究助理、研究助理教授、研究副教授，以及高级生物技术和医学研究中心助理研究员和研究员。2000年11月起，任中科院中国科学院上海生命科学研究院生化细胞所研究员，为中科院“百人计划”引进的杰出青年学术带头人，获得2001年国家杰出青年基金资助，2006年入选国家人事部“新世纪百千万人才工程”国家级人选。现任生化细胞所学术委员会副主任，分子生物学国家重点实验室副主任，“中国生物化学与分子生物学学会”理事、“蛋白质组学专业委员会”副主任委员、“蛋白质科学专业委员会”常务理事；“中国生物物理学会”理事；“中国晶体学会”常务理事；“亚洲晶体学会”常务理事等；中国《生物化学与生物物理学报》《生物化学与生物物理进展》和《生命的化学》编委、英国《The Biochemical Journal》编辑顾问委员会委员等

研究领域为结构生物学，研究工作主要是运用蛋白质结晶学、分子生物学、生物化学、细胞生物学等方法，研究生物大分子的结构和功能。目前研究工作主要围绕一些具有重要生物学意义、并且与重要疾病相关的人源蛋白质的结构和功能进行研究，特别是参与染色质修饰的蛋白质、参与营养和能量调节的mTOR信号转导通路的蛋白质、以及参与合成和分解代谢过程的重要酶蛋白等。近五年来主持、参与并完成国家、科学院和地方政府的多项重大研究项目。现已在国际重要学术刊物上发表研究论文100多篇，其中包括Nature, Nature Struct Biol, PNAS, embo J, J Biol Chem, Nucleic Acid Res, Structure, J 摩尔 Biol, Biochem J, Virology等。这些研究工作不仅阐述了一些重要蛋白质分子的生物功能的结构基础、反应机理、结构和功能的关系等一系列科学问题，具有重大的科学意义；同时还为探索与这些蛋白的功能失调相关的疾病的发病机理、寻找疾病诊断的新靶标和新方法、设计和开发抗病毒和抗疾病药物等奠定了分子基础，具有重要的潜在应用价值。

丁建平所教授课程包括结构生物学、生物化学与分子生物学、实验生物学、高级生化以及在生物化学夏令营中教授高级生化课程。

参考文献：

[1]Yabing Liu, Lejia Hu, Tengfei Ma, Jun Yang, Jianping Ding. Insights into the inhibitory mechanisms of NADH on the αγ heterodimer of human NAD-dependent isocitrate dehydrogenase. SCIENTIFIC REPORTS[J]. 2018, 第 5 作者8(1): 1-12.

[2]Zhong, Chen, Huo, Rongfen, Hu, Kuan, Shen, Jinlong, Li, Dangsheng, Li, Ningli, Ding, Jianping. Molecular basis for the recognition of CCN1 by monoclonal antibody 093G9. JOURNAL OF MOLECULAR RECOGNITION[J]. 2017, 第 7 作者 通讯作者 30(11).

[3]Ma, Tengfei, Peng, Yingjie, Huang, Wei, Ding, Jianping. Molecular mechanism of the allosteric regulation of the alpha gamma heterodimer of human NAD-dependent isocitrate dehydrogenase. SCIENTIFIC REPORTS[J]. 2017, 第 4 作者 通讯作者.

[4]Tao, Ye, Zhong, Chen, Zhu, Junjun, Xu, Shutong, Ding, Jianping. Structural and mechanistic insights into regulation of HBO1 histone acetyltransferase activity by BRPF2. NUCLEIC ACIDS RESEARCH[J]. 2017, 第 5 作者 通讯作者 45(10): 5707-5719.

[5]Zhong, Chen, Shen, Jinlong, Zhang, Huibing, Li, Guangyi, Shen, Senlin, Wang, Fang, Hu, Kuan, Cao, Longxing, He, Yongning, Ding, Jianping. Cbln1 and Cbln4 Are Structurally Similar but Differ in GluD2 Binding Interactions. CELL REPORTS[J]. 2017, 第 10 作者 通讯作者 20(10): 2328-2340.

[6]Xu, Xiaoyan, Han, Lei, Zhao, Guixian, Xue, Shengjie, Gao, Yunzhen, Xiao, Jun, Zhang, Shicheng, Chen, Peng, Wu, Zhiying, Ding, Jianping, Hu, Ronggui, Wei, Bin, Wang, Hongyan. LRCH1 interferes with DOCK8-Cdc42-induced T cell migration and ameliorates experimental autoimmune encephalomyelitis. JOURNAL OF EXPERIMENTAL MEDICINE[J]. 2017, 第 10 作者214(1): 209-226.

[7]Tianlong Zhang, Rong Wang, Zhijing Wang, Xiangxiang Wang, Fang Wang, Jianping Ding. Structural basis for Ragulator functioning as a 脚手架 in membrane-anchoring of Rag GTPases and mTORC1. NATURE COMMUNICATIONS[J]. 2017, 第 6 作者 通讯作者 8(1).

[8]Zhang, Shicheng, Wang, Linlin, Tao, Ye, Bai, Tuya, Lu, Rong, Zhang, Tianlong, Chen, Jiangye, Ding, Jianping. Structural basis for the functional role of the Shu complex in homologous recombination. NUCLEIC ACIDS RESEARCH[J]. 2017, 第 8 作者 通讯作者 45(22): 13068-13079.

[9]Wang, Rong, Wang, Zhijing, Wang, Kaikai, Zhang, Tianlong, Ding, Jianping. Structural basis for targeting BIG1 to Golgi apparatus through interaction of its DCB domain with Arl1. JOURNAL OF MOLECULAR CELL BIOLOGY. 2016, 第 5 作者 通讯作者 8(5): 459-461.

[10]Wenshuai Wang, Xiaoyu Sun, Yanbing Li, Jinpeng Su, Zhiyang Ling, Tianlong Zhang, Fang Wang, Hong Zhang, Hualan Chen, Jianping Ding, Bing Sun. Human antibody 3E1 targets the HA stem region of H1N1 and H5N6 流行性感冒 A viruses. NATURE COMMUNICATIONS[J]. 2016, 第 10 作者 通讯作者 7(1).

[11]Xia, Jing, Wang, Rong, Zhang, Tianlong, Ding, Jianping. Structural insight into the arginine-binding specificity of CASTOR1 in amino acid-dependent mTORC1 signaling. CELL DISCOVERY[J]. 2016, 第 4 作者 通讯作者.

[12]Lv, Fengjuan, Zhang, Tianlong, Zhou, Zhen, Gao, Shuaixin, Wong, Catherine C L, Zhou, JinQiu, Ding, Jianping. Structural basis for Sfm1 functioning as a protein arginine methyltransferase. CELL DISCOVERY[J]. 2015, 第 7 作者 通讯作者 1: 15037.

[13]Qingyu Tang, Caifeng Liu, Chen Zhong, Jianping Ding. 晶体 Structures of Arabidopsis thaliana Nudix Hydrolase NUDT7 Reveal a Previously Unobserved Conformation. 分子植物：英文版[J]. 2015, 第 4 作者8(10): 1557-1559.

[14]Powis, Katie, Zhang, Tianlong, Panchaud, Nicolas, Wang, Rong, De Virgilio, Claudio, Ding, Jianping. 晶体 structure of the Ego1-Ego2-Ego3 complex and its role in promoting Rag GTPase-dependent TORC1 signaling. CELL RESEARCH[J]. 2015, 第 6 作者25(9): 1043-1059.

[15]Fang Yu, Fangyuan He, Hongyan Yao, Chengyuan Wang, Jianchuan Wang, Jianxu Li, Xiaofeng Qi, Hongwei Xue, Jianping Ding, Peng Zhang. Structural basis of intramitochondrial phosphatidic acid transport mediated by Ups1-Mdm35 complexStructural basis of intramitochondrial phosphatidic acid transport mediated by Ups1-Mdm35 complex. 2015, 第 9 作者.

[16]Li, Wenjing, Zhang, Tianlong, Ding, Jianping. Molecular basis for the substrate specificity and 催化 mechanism of thymine-7-hydroxylase in fungi. NUCLEIC ACIDS RESEARCH[J]. 2015, 第 3 作者 通讯作者 43(20): 10026-10038.

[17]Zhang, Lun, Wang, JianChuan, Hou, Li, Cao, PengRong, Wu, Li, Zhang, QianSen, Yang, HuaiYu, Zang, Yi, Ding, JianPing, Li, Jia. Functional Role of Histidine in the Conserved His-x-Asp Motif in the 催化 Core of Protein Kinases. SCIENTIFIC REPORTS[J]. 2015, 第 9 作者5(1).

[18]Zhang, Shicheng, Zhang, Tianlong, Yan, Minghui, Ding, Jianping, Chen, JiangYE 晶体 structure of the WOPR-脱氧核糖核酸 complex and implications for Wor1 function in white-opaque switching of Candida albicans. CELL RESEARCH[J]. 2014, 第 4 作者24(9): 1108-1120.

[19]Zhang, Zhe, Zhang, Tianlong, Wang, Shanshan, Gong, Zhou, Tang, Chun, Chen, Jiangye, Ding, Jianping. Molecular mechanism for Rabex-5 GEF activation by Rabaptin-5. ELIFE[J]. 2014, 第 7 作者 通讯作者.

[20]Zhang, Zhe, Wang, Shanshan, Shen, Tong, Chen, Jiangye, Ding, Jianping. 晶体 Structure of the Rab9A-RUTBC2 RBD Complex Reveals the Molecular Basis for the Binding Specificity of Rab9A with RUTBC2. STRUCTURE[J]. 2014, 第 5 作者 通讯作者 22(10): 1408-1420.

[21]Zhang, Zilong, Wu, Jian, Lin, Wei, Wang, Jin, Yan, Han, Zhao, Wei, Ma, Jun, Ding, Jianping, Zhang, Peng, Zhao, GuoPing. Subdomain II of alpha-Isopropylmalate Synthase Is Essential for Activity INFERRING A MECHANISM OF FEEDBACK INHIBITION. JOURNAL OF BIOLOGICAL 化学[J]. 2014, 第 11 作者289(40): 27966-27978.

[22]Huang, Wei, Gong, Zhen, Li, Jian, Ding, Jianping. 晶体 structure of Drosophila melanogaster 色氨酸 2,3-di氧ase reveals insights into substrate recognition and 催化 mechanism. JOURNAL OF STRUCTURAL BIOLOGY[J]. 2013, 第 4 作者 通讯作者 181(3): 291-299.

[23]Li, Sisi, Du, Jiamu, Yang, Hui, Yin, Juan, Ding, Jianping, Zhong, Jiang. Functional and structural characterization of DNMT2 from Spodoptera frugiperda. JOURNAL OF MOLECULAR CELL BIOLOGY[J]. 2013, 第 5 作者 通讯作者 5(1): 64-66.

[24]Yang, Hui, Zhang, Tianlong, Tao, Ye, Wang, Fang, Tong, Liang, Ding, Jianping. Structural insights into the functions of the FANCM-FAAP24 complex in 脱氧核糖核酸 repair. NUCLEIC ACIDS RESEARCH[J]. 2013, 第 6 作者 通讯作者 41(22): 10573-10583.

[25]Ding Jianping. 晶体 structures of isoorotate decarboxylases reveal a novel catalytic mechanism of 5-carboxyl-uracil decarboxylation and shed lights on the search for 脱氧核糖核酸 decarboxylase. Cell Res.. 2013, 第 1 作者 通讯作者.

[26]Ding, Jianping, Wang, Jianchuan, Zhong, Chen, Wang, Fang. 晶体 structures of S6K1 provide insights into the regulation mechanism of S6K1 by the hydrophobic motif. FASEB JOURNAL. 2013, 第 1 作者.

[27]Ding Jianping. Structures of trans-2-enoyl-CoA reductases from 梭菌属 acetobutulicum and Treponema denticola: insights into the substrate specificity and the catalytic mechanism. BIOCHEMJ. 2013, 第 1 作者 通讯作者.

[28]Zha, Manwu, Zhong, Chen, Ou, Ying, Han, Li, Wang, Jianchuan, Ding, Jianping. 晶体 Structures of Human CaMKI alpha Reveal Insights into the Regulation Mechanism of CaMKI. PLOS ONE[J]. 2012, 第 6 作者 通讯作者 7(9).

[29]Li Wenjing, Zhong Chen, Li Lei, Sun Bingfa, Wang Weiyi, Xu Shutong, Zhang Tlanlong, Wang Chunguang, Bao Lhn, Ding Jianping. Molecular basis of the acetyltransferase activity of MEC-17 towards -tubulin. CELL RESEARCH[J]. 2012, 第 10 作者22(12): 1707-1711.

[30]Ding Jianping. Saccharomyces cerevesiae MHF complex structurally resembles the histones (H3H4)2 heterotetramer and functions as a heterotetramer. Structure. 2012, 第 1 作者 通讯作者.

[31]Ding Jianping. Ego3 functions as a homodimer to mediate the interaction between Gtr1-Gtr2 and Ego1 within the TORC1 activating EGO complex. Structure. 2012, 第 1 作者 通讯作者.

[32]Ding Jianping. A novel 钙binding site of von illebrand factor A2 domain regulates its cleavage by ADAMTS13. Blood. 2011, 第 1 作者 通讯作者.

[33]Bingfa Sun, Shunling Guo, Qingyu Tang, Chen Li, Rong Zeng, Zhiqi Xiong, Chen Zhong, Jianping Ding. Regulation of the histone acetyltransferase activity of hMOF via autoacetylation of Lys274. 细胞研究：英文版[J]. 2011, 第 8 作者21(8): 1262-1266.

[34]Ding Jianping. Structural and biochemical studies of human lysine methyltransferase Smyd3 reveal unique features of the enzyme. Nucleic Acids Res.. 2011, 第 1 作者 通讯作者.

[35]Wang, Bing, Peng, Yingjie, Zhang, Tianlong, Ding, Jianping. 晶体 structures and kinetic studies of human Kappa class glutathione transferase provide insights into the 催化 mechanism. BIOCHEMICAL JOURNAL[J]. 2011, 第 4 作者 通讯作者 439: 215-225.

[36]Ding Jianping. Structure of human lysine methyltransferase Smyd2 reveals insights into the substrate divergence in Smyd protein. Cell Biol.. 2011, 第 1 作者 通讯作者.

[37]Chen Zhong Jianping Ding. New G-protein-coupled receptor structures provide insights into the recognition of CXCL12 and HIV-1 gp120 by CXCR4. 生物化学与生物物理学报：英文版[J]. 2011, 43(5): 337-338.

[38]Chang, Yuanyuan, Wu, Jian, Tong, XiaJing, Zhou, JinQiu, Ding, Jianping. 晶体 structure of the 催化 core of Saccharomyces cerevesiae histone demethylase Rph1: insights into the substrate specificity and catalytic mechanism. BIOCHEMICAL JOURNAL[J]. 2011, 第 5 作者 通讯作者 433: 295-302.

[39]Ding Jianping. Structural basis of the immunosuppressive mechanism of therapeutic antibody daclizumab. Cell Res.. 2010, 第 1 作者 通讯作者.

[40]Li, Yingjie, Du, Jiamu, Zhang, Peng, Ding, Jianping. 晶体 structure of human 铜 homeostasis protein CutC reveals a potential copper-binding site. JOURNAL OF STRUCTURAL BIOLOGY[J]. 2010, 第 4 作者 通讯作者 169(3): 399-405.

[41]Ding Jianping. Crystal structure of Saccaromyces cerevisae tryptophanyl-转运RNA synthetase: new insights into the mechanism of trptophan activation and implications for anti-fungal drug 设计 Nucleic Acids Res.. 2010, 第 1 作者 通讯作者.

[42]Ding Jianping. 晶体 structure of P. Horikoshi tryptophanyl-转运RNA synthetase and structure-based phylogenetic analysis suggest an archaeal Origin of tryptophanyl-tRNA synthetases. Nucleic Acids Res.. 2010, 第 1 作者 通讯作者.

[43]Bei Yang, Chen Zhong, Yingjie Peng, Zheng Lai, Jianping Ding. Molecular mechanisms of ＂off-on switch＂ of activities of human IDH1 by tumor-associated mutation R132H. 细胞研究：英文版[J]. 2010, 第 5 作者1188-1200.

[44]Hui Yang, Jianchuan Wang, Baozhen Peng, Huaizu Guo, Yajun Guo, Jianping Ding, Jiamu Du, Dapeng Zhang. Structural Basis for the Blockage of IL-2 Signaling by Therapeutic Antibody Basiliximab. AMERICAN ASSOCIATION OF IMMUNOLOGISTS. 2010, 第 6 作者.

[45]Ding Jianping. Molecular basis of the acceleration of the nucleotide exchange of Rheb by TCTP. J. Biol. Chem.. 2009, 第 1 作者 通讯作者.

[46]Du, Jiamu, Yang, Hui, Guo, Yajun, Ding, Jianping. Structure of the Fab fragment of therapeutic antibody Ofatumumab provides insights into the recognition mechanism with CD20. MOLECULAR IMMUNOLOGY[J]. 2009, 第 4 作者46(11-12): 2419-2423.

[47]Sheng Li, Hao Wang, Baozhen Peng, Meilan Zhang, Daipong Zhang, Sheng Hou, Yajun Guo, Jianping Ding. Efalizumab binding to the LFA-1 α L I domain blocks ICAM-1 binding via steric hindrance. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2009, 第 8 作者106(11): 4349-4354.

[48]Zhang, Tianlong, Li, Sheng, Zhang, Yichen, Zhong, Chen, Lai, Zheng, Ding, Jianping. 晶体 Structure of the ARL2-GTPBART Complex Reveals a Novel Recognition and Binding Mode of Small GTPase with Effector. STRUCTURE[J]. 2009, 第 6 作者 通讯作者 17(4): 602-610.

[49]Zhang, Peng, Ma, Jun, Zhang, Zilong, Zha, Manwu, Xu, Hai, Zhao, Guoping, Ding, Jianping. Molecular basis of the inhibitor selectivity and insights into the feedback inhibition mechanism of citramalate synthase from 钩端螺旋体属 interrogans. BIOCHEMICAL JOURNAL[J]. 2009, 第 7 作者 通讯作者 421: 133-143.

[50]Ding Jianping. Structural modeling and biochemical studies reveal insights into the molecular basis of the recognition of ?-2-microglobulin by antibody BBM.1. J. Mol. Recognition. 2009, 第 1 作者 通讯作者.

[51]Ma, Jun, Zhang, Peng, Zhang, Zilong, Zha, Manwu, Xu, Hai, Zhao, Guoping, Ding, Jianping. Molecular basis of the substrate specificity and the catalytic mechanism of citramalate synthase from 钩端螺旋体属 interrogans. BIOCHEMICAL JOURNAL[J]. 2008, 第 7 作者 通讯作者 415(1): 45-56.

[52]Shen, Ning, Zhou, Minyu, Yang, Bei, Yu, Yadong, Dong, Xianchi, Ding, Jianping. 催化 mechanism of the 色氨酸 activation reaction revealed by crystal structures of human tryptophanyl-tRNA synthetase in different enzymatic states. NUCLEIC ACIDS RESEARCH[J]. 2008, 第 6 作者 通讯作者 36(4): 1288-1299.

[53]Du, Jiamu, Hou, Sheng, Zhong, Chen, Lai, Zheng, Yang, Hui, Dai, Jianxin, Zhang, Dapeng, Wang, Hao, Guo, Yajun, Ding, Jianping. Molecular basis of recognition of human osteopontin by 23C3, a potential therapeutic antibody for treatment of rheumatoid 关节炎 JOURNAL OF MOLECULAR BIOLOGY[J]. 2008, 第 10 作者382(4): 835-842.

[54]Sun, Bingfa, Hong, Jing, Zhang, Peng, Dong, Xianchi, Shen, Xu, Lin, Donghai, Ding, Jianping. Molecular Basis of the Interaction of Saccharomyces cerevisiae Eaf3 Chromo Domain with Methylated H3K36. JOURNAL OF BIOLOGICAL 化学[J]. 2008, 第 7 作者283(52): 36504-36512.

[55]Ding Jianping. Isoquinoline-1,3,4-trione derivatives inactivates caspase-3 by generation of reactive oxygen 物种 J. Biol. Chem.. 2008, 第 1 作者 通讯作者.

[56]Du, Jiamu, Wang, Hao, Zhong, Chen, Peng, Baozhen, Zhang, Meilan, Li, Bohua, Hou, Sheng, Guo, Yajun, Ding, Jianping. 晶体 structure of chimeric antibody C2H7 Fab in complex with a CD20 多肽 MOLECULAR IMMUNOLOGY[J]. 2008, 第 9 作者45(10): 2861-2868.

[57]Ding Jianping. Molecular mechanism of ADPR hydrolysis by human NUDT5 from structural and kinetic studies. J. Mol. Biol.. 2008, 第 1 作者 通讯作者.

[58]Ma Tengfei, Peng Yingjie, Huang Wei, Liu Yabing, Ding Jianping. The β and γ subunits play distinct functional roles in the α 2 βγ heterotetramer of human NAD-dependent isocitrate dehydrogenase. SCIENTIFIC REPORTS. 第 5 作者.

[59]Xu Shaoqiong, Zhang Tianlong, Kompella Shiva N., Yan Mengdi, Lu Aiping, Wang Yanfang, Shao Xiaoxia, Chi Chengwu, Adams David J., Ding Jianping, Wang Chunguang. Conotoxin αD-GeXXA utilizes a novel strategy to antagonize nicotinic 乙酰胆碱 receptors. SCIENTIFIC REPORTS. 第 10 作者5.

[60]Peng Yingjie, Zhong Chen, Huang Wei, Ding Jianping. Structural studies of Saccharomyces cerevesiae mitochondrial NADP-dependent isocitrate dehydrogenase in different enzymatic states reveal substantial conformational changes during the catalytic reaction. PROTEIN SCIENCE : A PUBLICATION OF THE PROTEIN SOCIETY. 第 4 作者17(9): 1542-1554.

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