陈宝安是东南大学医学院教授，专业领域为血液病与肿瘤学。他是全国知名的专家，备受尊重和信任。

1979年毕业于南京铁道医学院医疗系（今东南大学医学院），美国MD Aderson Cancer Center、加利福尼亚大学伯克利分校、德国海德堡大学等多所世界著名大学高级访问学者。

毕业后先后在南京铁道医学院完成硕士，复旦大学上海医学院（今复旦大学上海医学院）完成博士学位，在乌尔姆大学血液肿瘤科完成博士后研究工作。

现任东南大学附属中大医院血液科学科带头人、骨髓增生异常综合征研究所所长、肿瘤学系主任。兼任中国抗癌协会临床肿瘤学协作专业委员会执行委员、江苏省抗癌协会理事、中华医学会江苏省血液学会副主任委员、中华医学会南京血液学会前主任委员。

研究方向

肿瘤耐药方面的研究

白血病治疗失败的主要原因之一为多药耐药，在国家自然科学基金资助下，研究发现汉防己甲素是一种非选择性钙离子通道阻滞剂，它能提高化疗药物对白血病细胞的抑制率，且对正常的骨髓细胞无抑制作用。心肌毒副作用低，实验用量临床可以接受；他莫西芬可通过改善膜结构，竟争性抑制膜糖蛋白对化疗药物的转运。二者单独应用均能逆转多药耐药。经专家评定，此方面研究已达到国际先进水平。

基因技术的研究

已完成了检测肿瘤微转移的基因芯片的研究，并获得了国家知识产权及发明专利；并进行了蛋白质芯片的研究，《应用蛋白质芯片检测多药耐药蛋白表达水平》于中华肿瘤杂志2005年发表。目前由江苏省卫生厅资助的重点项目“微转移基因芯片研制及在消化道恶性肿瘤中的应用研究”正在进行中。

阻断肿瘤新生血管的物理原理及生物效应

针对肿瘤血管生成的治疗措施可成为一个新颖抗癌途径。目前此方面的研究主要集中在对肿瘤血管生成因子，和抗内皮细胞增殖和迁移的方面。通过前期研究，发现通过超声空化及空化核的增强效应，直接损伤肿瘤新生血管，并已完成了低功率超声辐射二氧化碳微泡剂致使肿瘤血管拴塞的实验研究，。将进一步对动物移植瘤做进一步的研究，并准备进行临床研究，以期建立无创诱导致肿瘤新生血管内皮细胞损伤及阻断肿瘤血液供应的新方法。

造血干细胞移植

近几年开展了非清髓造血干细胞移植36例，疗效满意，治疗相关毒副反应小，经济费用较低，使白血病患者摆脱了病痛，目前处于国内领先水平，在全国范围内产生了深远影响。

1. 国家自然科学基金面上项目：汉防已甲素和角罗西芬逆转白血病细胞多药耐药的机理研究（编号：39970832，研究年限：2000.11－2002.12）已结题

2. 南京市重大课题：非清髓造血干细胞移植治疗白血病（编号：YQ0008，研究年限：2001－2004）已结题

3. 江苏省卫生厅科技发展基金：生物疗法在慢性白血病ASCT体外净化作用（编号：H200344，研究年限：2003－2005）已结题

4. 东南大学东南大学附属中大医院重大课题：非清髓造血干细胞移植治疗血液病（编号：2003YJ02，研究年限：2003－2005）已结题

5. 高等学校博士学科点专项科研基金：共聚合汉防己甲素和化疗药物的磁性纳米四氧化三铁颗粒在逆转恶性血液病多药耐药中的机理研究（编号：20070286042，研究年限：2008－2010）已结题

6. 国家自然基金面上项目：共聚合汉防己甲素和化疗药物的磁性纳米四氧化三铁颗粒在逆转恶性血液病多药耐药中的机理研究（编号：30740062，研究年限：2008－2009）已结题7. 国家自然基金面上项目：磁性纳米四氧化三铁颗粒共聚合柔红霉素和5－溴汉防己甲素逆转恶性血液病多药耐药的机理研究（编号：30872970，研究年限：2009－2011）已结题8. 国家高技术研究发展计划（863计划）子课题：急性白血病的治疗（研究年限：2009－2011）已结题

9. 国家高技术研究发展计划（863计划）子课题：超灵敏纳米多孔生物传感器件的研究与开发（编号：32007AA022007，研究年限：2009－2011）已结题

10. 国家重点基础研究发展计划（973计划）子课题：基于仿生分子识别的传感与成像方法研究及其系统设计（编号：2010CB732404，研究年限：2009-2015）在研

11. 国家科技支撑计划课题（十一五）子课题：骨髓增生异常综合征的规范化诊断与治疗策略研究（编号：2008BAI61B02，研究年限：2008－2010）已结题

12. 国家自然基金面上项目：化疗药和中药与转铁蛋白纳米载体的设计及逆转白血病耐药的机制研究（编号：81170492，研究年限：2012－2015）在研

13. 国家高技术研究发展计划（863计划）子课题：针对生物标志物检测的低成本检测系统的研制（编号：2012AA022703，研究年限：2012－2016）在研

14. 国家自然基金面上项目：血小板靶向载药系统的研制及其抗白血病效应的研究（编号：81370673，研究年限：2014－2017）在研

15. 江苏省科技厅医学重点项目：江苏省复发和难治性白血病的规范化治疗（编号：BL2014078，研究年限：2014－2017）在研

1.CaiX, Cai X, Wang C,Chen BA*, Hua W, Shen Fet al. Antitumor efficacy of DMSA modified 四氧化三铁 magneticnanoparticles combined with 砷 trioxide and adriamycin in Raji cells.J Biomed Nanotech2014;10(2):251-261.

2.ChangH, Wang X, Shiu KK, Zhu Y, Wang J, Li Q,Chen BA*et al. Layer-by-layer assembly of graphene, Au andpoly(toluidine 蓝色 O) films sensor for evaluation of oxidative stress of tumorcells elicited by 氢 过氧化物Biosensors\u0026 Bioelectronics2013;41:789-794.

3.ChengJ, Cheng L,Chen BA*, Xia G, Gao C, Song Het al. Effect of magnetic nanoparticles of 四氧化三铁 and wogonin onthe reversal of multidrug resistance in K562/A02 细胞 谱线 Int J Nanomedicine2012;7:2843-2852.

4.FangL,Chen BA,Liu S, Wang R, Hu S, Xia G,Chen BA*et al.Synergistic effect of a 组合 of nanoparticulate 四氧化三铁 and gambogic acidon phosphatidyl肌醇 3-kinase/Akt/Bad pathway of LOVO cells. Int JNanomedicine2012;7:4109-4118.

5.JiangN, Zhu X, Zhang H, Wang X, Zhou X, Gu J,Chen BA*et al. The relationship between methylenetetrahydrofolatereductase polymorphism and hematological malignancy.Clin Lab2014;60(5):767-774.

6.JinN, Malcherek G, Mani J, Zurleit R, Schmitt A,Chen BAet al. Suppression of 巨细胞病毒specific CD8(+)T cells by everolimus.Leuk Lymphoma2014;55(5):1144-1150.

7.LiK,Chen BA*,Xu L, Feng J, Xia G, Cheng Jet al.Reversal of multidrug resistance by cisplatin-loaded magnetic 四氧化三铁nanoparticles in A549/DDP lung cancer cells in vitro and in vivo Int J Nanomedicine 2013;8:1867-1877.

8.LiangG, Li J, Sun B, Li S, Lu L, Wang Y,Chen BA*et al. Deep sequencing reveals complex mechanisms ofmicroRNA deregulation in colorectal cancer.IntJ 肿瘤学2014;45(2):603-610.

9.LuX, Zhu A, Cai X, Jia Z, Han W, Ma L,Chen BA*et al. Role of NKG2D in 细胞因子induced killer cellsagainst multiple myeloma cells.CancerBio Therapy2012;13(8):623-629.

10.MouY, Hou Y,Chen BA*, Hua Z, Zhang Y, Xie Het al. In vivo migration of dendritic cells labeled with syntheticsuperparamagnetic iron 氧化物 Int J Nanomedicine 2011;6:2633-2640.

11.RenY, Zhang H,Chen BA*, Cheng J, Cai X, Liu Ret al. Multifunctional magnetic 四氧化三铁 nanoparticles combined withchemotherapy and hyperthermia to overcome multidrug resistance. Int J Nanomedicine2012;7:2261-2269.

12.SongG, Gu L, Li J, Tang Z, Liu H,Chen BA*et al. Serum microRNAexpression profiling predict response to R-CHOP treatment in diffuse large Bcell lymphoma patients.Ann Hematol2014.e-pub ahead of print 2014/05/27

13.WangC, Cai X,Chen BA*, He Z, Chen Z, Cen Jet al. Up-regulation of tissue inhibitor of metalloproteinase-2promotes SHI-1 cell invasion in nude 鼠科Leuk 淋巴瘤2013;54(12):2707-2711.

14.WangC, Zhang H, Chen Y, Shi F,Chen BA*. Gambogic acid-loaded magnetic Fe(3)O(4)nanoparticles inhibit Panc-1 pancreatic cancer cell proliferation and migrationby inactivating transcription factor ETS1. Int J Nanomedicine2012;7:781-787.

15.Wang F, Zhang W, Guo L, Bao W,Jin N, Liu R,Chen BA*et al. Gambogic acid suppresses hypoxia-inducedhypoxia-inducible factor-1alpha /vascular endothelial growth factor expressionvia inhibiting phosphatidylinositol 3-kinase/Akt/mammalian target protein ofrapamycin pathway in multiple myeloma cells.Cancer Sci2014. e-pub ahead of print 2014/06/04.

16.WangL, Zhang H,Chen BA*, Xia G, Wang S, Cheng Jet al. Effect of magnetic nanoparticleson apoptosis and cell cycle induced by wogonin in Raji cells. Int J Nanomedicine2012;7:789-798.

17.WangX, Wang X, Gao S, Zheng Y, Tang M,ChenBA*. A 固体state electrochemiluminescencesensing platform for detection of catechol based on novel luminescent compositenanofibers.Talanta2013;107:127-132.

18.WenJ, Jiang S, Chen Z, Zhao W, Yi Y, Yang R,Chen BA* et al.Apoptosis selectively induced in BEL-7402 cells byfolic acid-modified magnetic nanoparticles combined with 100 Hz magnetic field.Int J Nanomedicine2014;9:2043-2050.

19.XuP,Chen BA*,Feng J, Cheng L, Xia G, Li Yet al.Polymorphisms in XPC provide prognostic information in acute myeloid 白血病IntJ 血液学2012;96(4):450-460.

20.XuP, Li J,Chen BA*, Wang X, Cai X, Jiang Het al. The real-时间 neurotoxicityanalysis of 四氧化三铁 nanoparticles combined with daunorubicin for rat brain invivoJBiomed Nanotechnology2012;8(3):417-423.

21.XuP, Li J, Shi L, Selke M,Chen BA*, Wang X. Synergetic effect of functionalcadmium-碲 quantum dots conjugated with gambogic acid for HepG2cell-labeling and proliferation inhibition. Int J Nanomedicine2013;8:3729-3736.

22.XuY, Wang Y, Li XM, Huang Q, Chen W, Liu R,Chen BA*et al. Study on the release of fenofibrate nanosuspension invitro and its correlation with in situ intestinal and in vivo absorptionkinetics in 家鼠属Drug Dev Indus Pharmacy2014;40(7):972-979.

23.YangZ,Chen BA*,Pei X, Shangguan F. Multiplex analysis of tumor multidrug-resistance genesexpression with photonic suspension array.TheAnalyst2012;137(14):3343-3348.

24.ZhangH, Wang C,Chen BA*, Wang X. Daunorubicin-TiO2 nanocompositesas a "smart" pH-responsive drug delivery system. Int J Nanomedicine2012;7:235-242.

25.ZhongY, Wu J,Chen BA*, Ma R, Cao H, Wang Zet al. Investigation and analysis of single nucleotidepolymorphisms in Janus kinase/signal transducer and activator of transcriptiongenes with 白血病Leuk Lymphoma2012;53(6):1216-1221.

26. Zhang HJ,Chen BA*,Jiang H, Wang CL, Wang HP, Wang XM. A strategy for ZnO nanorod mediatedmulti-mode cancer treatment. Biomaterials. 2011; 32(7):1906-14.

27.Chen BA*, Wu WW, WangXM. Magnetic Iron 氧化物 Nanoparticles for Tumor-targeted Therapy. Curr CancerDrug Targets 2011; 11(2):184-9.

28. Zhang HJ, Jiang H, Sun FF, Wang HP, Zhao J,Chen BA*, Wang XM. Rapid diagnosis of multidrug resistance in cancerby electrochemical sensor based on 碳 nanotubes-drug supramolecularnanocomposites. Biosens Bioelectron. 2011; 26(7):3361-6.

29. Song M, Zhang RR, Dai YY, Gao F, Chi H, Lv G,Chen BA,* Wang XM. The in vitro inhibitionof multidrug resistance by combined nanoparticulate titanium dioxide and UV irradition.Biomaterials. 2006; 27(23):4230-8.

30.Chen BA*, Yin L, ChengJ, Ding JH, Gao C, Sun YY, Zhao G, Wang J, Bao W, Xia GH, Gao F, Wang XM.Effect of D, L-threo-1-phenyl-2-decanoylamino-3-morpholino-1 -propanol andtetrandrine on the reversion of multidrug resistance in K562/A02 cells.血液学 2011; 16(1):24-30.

31. Wu WW,Chen BA*, ChengJ, Wang J, Xu WL, Liu LJ, Xia GH, Wei H, Wang XM, Yang M, Yang L, Zhang Y, XuC, Li J. Biocompatibility of 四氧化三铁/DNR magnetic nanoparticles inthe treatmentof hematologic malignancies. Int J Nanomedicine. 2010; 5:1079-84.

32. Wang J, Chen Y,Chen BA*,Ding JH, Xia GH, Gao C, Cheng J, Jin N, Zhou Y, Li XM, Tang M, Wang XM.Pharmacokinetic parameters and tissue distribution of magnetic Fe(3)O(4) nanoparticlesin 鼠科 Int J Nanomedicine. 2010; 5:861-6.

33.Chen BA*, Mao P, ChengJ, Gao F, Xia GH, Xu WL, Shen HL, Ding JH, Gao C, Sun Q, Chen W, Chen N, LiuLJ, Li XM, Wang XM. Reversal of multidrug resistance by magnetic 四氧化三铁nanoparticle copolymerizating daunorubicin and MDR1 shRNA expression 向量 inleukemia cells. Int J Nanomedicine. 2010; 5:437-4.

34.Chen BA*, Jin N, WangJ, Ding JH, Gao C, Cheng J, Xia GH, Gao F, Zhou Y, Chen Y, Zhou G, Li XM, ZhangY, Tang M, Wang XM. The effect of magnetic nanoparticles of Fe(3)O(4) on immunefunction in normal ICR 鼠科 Int J Nanomedicine. 2010; 5:593-9.

35. Zhang HJ, Jiang H, Wang XM,Chen BA*. Reversion of multidrugresistance in tumor by biocompatible nanomaterials. Mini Rev Med Chem. 2010;10(8):737-45.

36. Zhong YJ,Chen BA*,Feng JF, Cheng L, Li Y, Qian J, Ding JH, Gao F, Xia GH, Chen N, Lu Z. Theassociations of Janus kinase-2 (JAK2) A830G polymorphism and the treatment outcomesin patients with acute myeloid 白血病. Leuk 淋巴瘤 2010; 51(6):1115-20.

37. Zhu XL, Zhang HJ, Lin Y, Chen P, Min J, Wang Z, Xiao W,Chen BA*. Mechanisms of gambogicacid-induced apoptosis in non-small cell lung cancer cells in relation to transferrinreceptors. J Chemother. 2009; 21(6):666-72.

38. Pei XP,Chen BA*, LiL, Gao F, Jiang Z. Multiplex tumor marker detection with new chemiluminescentimmunoassay based on silica colloidal 晶体 beads. Analyst. 2010; 135(1):177-81.

39.Chen BA*, Liang YQ, WuWW, Cheng J, Xia GH, Gao F, Ding JH, Gao C, Shao Z, Li G, Chen W, Xu WL, SunXC, Liu LJ, Li XM, Wang XM. Synergistic effect of magnetic nanoparticles ofFe(3)O(4) with gambogic acid on apoptosis of K562 leukemia cells. Int J Nanomedicine.2009; 4:251-9.

40. Cheng J, Wu WW,Chen BA*,Gao F, Xu WL, Gao C, Ding JH, Sun YY, Song HH, Bao W, Sun XC, Xu C, Chen W,Chen N, Liu LJ, Xia GH, Li XM, Wang XM. Effect of magnetic nanoparticles of四氧化三铁 and 5-bromotetrandrine on reversal of multidrug resistance in K562/A02leukemic cells. Int J Nanomedicine. 2009; 4:209-16.

41. Pei XP, Zhao Y, Zhao X, Xu H,Chen BA*, Gu ZZ. Multiplex chemiluminescent immunoassay based onsilica colloidal 晶体 beads. J N N. 2009; 9(11):6320-5.

42. Sun N, Sun XC,Chen BA*,Cheng H, Feng JF, Cheng L, Lu ZH. MRP2 and GSTP1 polymorphisms and chemotherapyresponse in advanced non-small cell lung cancer. Cancer Chemoth Pharm. 2010;65(3):437-46.

43. Li Y, Deng Z, Xuan H, Zhu J, Ding B, Liu X,Chen BA*. Prolonged chronic phase in chronic myelogenous leukemiaafter homoharringtonine therapy. Chin Med J (Engl). 2009;122(12):1413-7.

44. Jiang Z,Chen BA*, XiaGH, Wu Q, Zhang Y, Hong T, Zhang W, Cheng J, Gao F, Liu LJ, Li XM, Wang XM. Thereversal effect of magnetic 四氧化三铁 nanoparticles loaded with cisplatin onSKOV3/DDP ovarian carcinoma cells. Int J Nanomedicine. 2009; 4:107-14.

45.Chen BA*, Cheng J, WuYN, Gao F, Xu WL, Shen HL, Ding JH, Gao C, Sun Q, Sun XC, Cheng H, Li G, ChenW, Chen N, Liu LJ, Li XM, Wang XM. Reversal of multidrug resistance by magnetic四氧化三铁 nanoparticle copolymerizating daunorubicin and 5-bromotetrandrine inxenograft nude-mice. Int J Nanomedicine. 2009; 4:73-8.

46.Chen BA*, Cheng J,Shen MF, Gao F, Xu WL, Shen HL, Ding JH, Gao C, Sun Q, Sun XC, Cheng H, Li G,Chen W, Chen N, Liu LJ, Li XM, Wang XM. Magnetic nanoparticle of 四氧化三铁 and5-bromotetrandrin interact synergistically to induce apoptosis by daunorubicin inleukemia cells. Int J Nanomedicine. 2009; 4:65-71.

47.Chen BA*, Dai YY, WangXM, Zhang R, Xu WL, Shen HL, Gao F, Sun Q, Deng X, Ding JH, Gao C, Sun Y, ChengJ, Wang J, Zhao G, Chen N. Synergistic effect of the combination of nanoparticulate四氧化三铁 and Au with daunomycin on K562/A02 cells. Int J Nanomedicine. 2008;3(3):343-50.

48.Chen BA*, Sun Q, WangXM, Gao F, Dai YY, Yin Y, Ding JH, Gao C, Cheng J, Li JY, Sun XC, Chen N, XuWL, Shen HL, Liu D. Reversal in multidrug resistance by magnetic nanoparticleof 四氧化三铁 loaded with adriamycin and 汉防己甲素 in K562/A02 leukemic cells. IntJ Nanomedicine. 2008; 3(2):277-86.

先后获教育部科技进步二等奖、江苏省科技进步二等奖。国家级课题5项，省部级二等奖3项。

1.王雪梅，张仁云，吕刚，吴春惠，李景源，高峰，程坚，陈宝安，付德刚，李小毛，

关之群. 治疗白血病的靶向磁性纳米药物及制备方法. 专利号：ZL 2005 1 0040657.1。

2.王雪梅，吴春惠，宋敏，李景源，张仁云，吴德洪，燕红，顾忠泽，陈宝安. 有机金

属碳硼烷靶向纳米制剂的制备方法及制成的靶向制剂. 专利号： ZL 2006 1 0096423.3。

个人贡献

主编《恶性肿瘤多药耐药的逆转》一部，参编著作多部，主持国家自然科学基金5项、参与“973”、“863” 、科技支撑等多项研究项目。

累计发表学术论文400余篇，其中SCI收录近百篇，主（参）编著作3部。