钟波，中国国籍，武汉大学生命科学学院教授，专业领域为病毒学。他的研究方向主要集中在抗病毒天然免疫、炎症反应与肿瘤发生等领域。

学习经历

2001.9－2005.6 中国地质大学外国语学院 英语专业 学士

2003.2－2005.6 武汉大学生命科学学院 生物科学专业 学士

2005.9－2010.6 武汉大学生命科学学院 细胞生物学 博士导师：舒红兵 院士

主要工作经历与任职情况　　2010.3－现在 武汉大学生命科学学院，病毒学国家重点实验室 教授、博导

主要社会兼职：

中国细胞生物学会青年委员会委员

中国免疫学会青年委员会委员

JBC，Acta Biochim Biophys Sin，Immunologic Research等杂志应邀审稿人

要研究领域及兴趣

本实验室主要从事抗病毒天然免疫信号转导、炎性细胞因子介导的炎症反应与肿瘤发生的分子机理的研究。我们主要以表达克隆、酵母双杂交以及蛋白质组学等多种手段，筛选参与调控抗病毒天然免疫以及炎症反应过程的蛋白，并通过基因敲除、转基因小鼠以及动物疾病模型研究这些蛋白在调控病毒感染、自身免疫性疾病以及肿瘤发生等过程中的功能与机制。

获奖与荣誉　　　2012 “全国百篇优秀博士论文”获得者，中国　　2012 美国免疫学家学会“Abstract Award”，美国　　2010 应邀参加第60届“诺贝尔获奖者大会”，德国　　2009 吴瑞奖，吴瑞基金会，美国

主持课题项目：　　1 国家自然科学基金面上项目：2014.01-2017.12　　2 国家重大基础研究计划子项目（973）：2014.01-2018.12　　3 教育部优秀博士论文获得者基金：2014.01-2017.12　　4 病毒学国家重点实验室研究骨干:2014.01-

代表性论文

1. Lin D, Zhang M, Zhang MX, Ren YJ, Zhao Q, Jin J, pan Z, Wu M, Shu HB, 越南盾 C,Zhong B*. Induction of USP25 by viral infection promotes innate antiviral responses by mediating the stabilization of TRAF3 and TRAF6.Proc Natl Acad Sci U S A. 2015 2015 Aug 24. pii: 201509968. [Epub ahead of print]. (* corresponding author)

2.Wei J, Lian H,Zhong B, Shu HB. Parafibromin is a component of IFNγ-triggered signaling pathways that facilitates JAK1/2-mediated tyrosine phosphorylation of STAT1.J Immunol.2015 Jul 31. pii: 1501111. [Epub ahead of print]

3.Deng T, Lin D, Zhang M, Zhao Q, Li W,Zhong B, Deng Y, Fu X. Differential expression of bone morphogenetic protein 5 in human lung squamous cell carcinoma and adenocarcinoma.Acta Biochim Biophys Sin.2015 47(7):557-63.

4.Lin D,Zhong B*. Regulation of cellular innate antiviral signaling by ubiquitin modification.Acta Biochim Biophys Sin.2015 47(3):149-155. (* corresponding author)

5.Liu X, Chen X,Zhong B, Wang A, Wang X, Chu F, Nurieva RI, Yan X, Chen P, Van der Flier LG, Nakatsukasa H, Neelapu SS, Chen W, Clevers H, Tian Q, Qi H, Wei L, Dong C. Transcription factor achaete-S.cute 同系物 2 initiates follicular T-helper-cell development.Nature. 2014, 507(7493):513-8.

6.Luo WW, Lian H,Zhong B, Shu HB, Li S. Krüppel-like factor 4 negatively regulates cellular antiviral immune response.Cell 摩尔 Immunol. 2014 Dec 22.

7.Zhou Q, Lin H, Wang S, Wang S, Ran Y, Liu Y, Ye W, Xiong X,Zhong B, Shu HB, Wang YY. The ER-associated protein ZDHHC1 is a positive regulator of 脱氧核糖核酸 病毒triggered, MITA/STING-dependent innate immune signaling.Cell Host Microbe.2014, 16(4):450-6.

8. Qin Y, Zhou MT, Hu MM, Hu YH, Zhang J, Guo L,Zhong B, Shu HB. RNF26 temporally regulates virus-triggered type I interferon induction by two distinct mechanisms.PLoS Pathog.2014, 10(9):e1004358.

9.Lei CQ, Zhang Y, Li M, Jiang LQ,Zhong B, Kim YH, Shu HB. ECSIT Bridges RIG-I-Like Receptors to VISA in Signaling Events of Innate Antiviral Responses.J Innate Immun.2015, 7(2):153-64.

10.Zhang Y, Lei CQ, Hu YH, Xia T, Li M,Zhong B, Shu HB. Krüppel-like factor 6 is a co-activator of NF-κB that mediates p65-dependent transcription of Selected downstream genes.J Biol Chem.2014, 289(18):12876-85.

11.Hu MM, Yang Q, Zhang J, Liu SM, Zhang Y, Lin H, Huang ZF, Wang YY, Zhang XD,Zhong B, Shu HB. TRIM38 inhibits TNFα- and IL-1β-triggered NF-κB activation by mediating lysosome-dependent degradation of TAB2/3.Proc Natl Acad Sci U S A.2014, 111(4):1509-14.

12.Lei CQ, Zhang Y, Xia T, Jiang LQ,Zhong B, Shu HB. FoxO1 negatively regulates cellular antiviral response by promoting degradation of IRF3. (2013).J Biol Chem.288, 12596-604.

13.Zhong B, Liu XK, Wang XH, Liu XD, Li HX, Darnay BR, Lin X, Sun SC and Dong C. Ubiquitin-specific Protease 25 regulates TLR4-dependent innate immune response through deubiquitination of TRAF3. (2013).Sci Signal. 6, ra35.

14.Liu XK#, Li HX#,Zhong B#, Blonska M, Gorjestani S, Yan M, Tian Q, Zhang DE, Lin X and Dong C. USP18 inhibits NF-κB and NFAT activation during Th17 differentiation by deubiquitinating the TAK1-TAB1 complex. (2013).J Exp Med.210, 1575-90. (#Co-first authors)

15.Zhong B, Liu XK, Wang XH, Chang SH, Liu XD, Wang AB, Reynolds JM, and Dong C. Negative regulation of IL-17-mediated signaling and inflammation by the ubiquitin-specific protease USP25. (2012).Nat Immunol.13, 1110-17.

16.Liu XD, Yan X,Zhong B, Nurieva RI, Wang A, Wang X, Martin-Orozco N, Wang Y, Chang SH, Esplugues E, Flavell RA, Tian Q, Dong C. Bcl6 expression specifies the T follicular helper cell program in vivo (2012).J Exp Med.209:1841-52.

17.Xu T#, Wang X#,Zhong B, Nurieva RI, Ding S, Dong C. Ursolic acid suppresses interleukin-17 (IL-17) production by selectively antagonizing the function of RORgamma t protein. (2011).J Biol Chem.286, 22707-10.

18.Lei CQ,Zhong B, Zhang Y, Zhang J, Wang S and Shu HB. 糖原 synthase kinase 3β regulates IRF3 transcription factor-mediated antiviral response via activation of the kinase TBK1. (2010).Immunity. 33, 878-89.

19.Zhong B, Zhang Y, Tan B, Liu TT, Wang YY and Shu HB. The E3 ubiquitin ligase RNF5 targets 病毒induced signaling adaptor for ubiquitination and degradation. (2010).J Immunol.184, 6249-6255.

20.Zhong B, Wang YY and Shu HB托尔斯港 Regulation of virus-triggered type I interferon signaling by cellular and viral proteins. (2010).Frontier in Biology5, 12-31.

21.Zhong B,Zhang L, Lei CQ, Li Y., Mao AP, Yang Y, Wang YY, Zhang XL and Shu HB. The ubiquitin ligase RNF5 regulates antiviral responses by mediating degradation of the adaptor protein MITA. (2009).Immunity30, 397-407.

22.Zhong B, Yang Y, Li S, Wang YY, Li Y, Diao FC, Lei CQ, He X, Zhang L, Tien, P and Shu HB. The adapter protein MITA links 病毒sensing receptors to IRF3 transcription factor activation. (2008).Immunity29, 538–550.

23.Zhong B, Tien P and Shu HB托尔斯港 Innate immune responses: crosstalk of signaling and regulation of gene transcription. (2006).Virology352, 14-21.

24.Wang YY, Liu LJ,Zhong B, Liu TT, Li Y, Yang Y, Ran Y, Li S, Tien P and Shu HB. WDR5 is essential for assembly of the VISA-associated signaling complex and 病毒triggered IRF3 and NF-kB activation. (2010).Proc Natl Acad Sci U S A.107, 815-820.

25.Mao AP, Li S,Zhong B, Li Y, Yan J, Li Q and Shu HB. Virus-triggered ubiquitination of TRAF3 by cIAP1/2 at the mitochondria is essential for induction of IFN-b and cellular antiviral response. (2010).J Biol Chem.285, 9470-9476.

26.Chen R, Zhang L,Zhong B, Tan B, Liu Y and Shu HB托尔斯港 Ubiquitin-specific protease 17 is involved in 病毒triggered type I interferon signaling. (2010).细胞 Res.20: 802-11.

27.Li S, Zheng H, Mao AP,Zhong B, Li Y, Liu Y, Gao Y, Ran Y, Tien P and Shu HB. Regulation of virus-triggered signaling by OTUB1- and OTUB2-mediated deubiquitination of TRAF3 and TRAF6. (2010).J Biol Chem.285, 4291-4297.

28.Li Y, Li C, Xue P,Zhong B, Mao AP, Ran Y, Chen H, Wang YY, Yang FQ and Shu HB. ISG56 is a negative regulator of 病毒triggered signaling and cellular antiviral response. (2009).Proc Natl Acad Sci U S A.106, 7945-50.

29.Daio FC, Li S, Tian Y, Zhang M, Xu LG, Zhang Y, Wang RP, Zhai Z,Zhong B, Tien P and Shu HB托尔斯港 Negative regulation of MDA5- but not RIG-I-mediated innate antiviral signaling by the dihydroxya. (2007).Proc Natl Acad Sci U S A.104, 11706-11711.

30.Tian Y#, Zhang Y#,Zhong B, Wang YY, Diao FC, Wang RP, Zhang M, Chen DY, Zhai Z and Shu HB. RBCK1 negatively regulates tumor necrosis factor- and interleukin-1-triggered NF-kappaB activation by targeting TAB2/3 for degradation. (2007).J Biol Chem. 282, 16776-11782. (#Co-first authors).

31.张煜，钟波，杨艳，舒红兵 TLRs与RLRs介导的细胞抗病毒反应信号转导及其调节机制. (2009).细胞生物学杂志31, 453-468.

32.钟波，舒红兵. 天然免疫模式识别受体与树突状细胞的发现和意义——2011年诺贝尔生理学或医学奖成果和相关研究.生命科学(2011). 23, 1147-1161.