李晓江，中国科学院遗传与发育生物学研究所分子发育生物学国家重点实验室，博士生导师。研究成果发表于《Nature》 《Nature Genetics》等国际核心刊物100余篇，累计引用率达到12000余次，h-index高达62。2008年起任华中科技大学基础医学院讲座教授；2010年入选中组部（中科院遗传发育所）。李晓江博士还兼任华中科技大学，中南大学与苏州大学的客座教授。

1977-1982年，南昌大学江西医学院医学专业学士

1983-1986年，苏州大学医学部药理学硕士

1987-1991年，美国Oregon Health Science University 药理学博士

1991-1995年，美国Johns Hopkins University 神经学科博士后

1995-1996年，美国Johns Hopkins University精神病学系助理教授

1996-2001年，美国Emory大学人类遗传学系助理教授

2001-2005年，美国Emory大学人类遗传学系终身副教授

2005年起，美国Emory大学人类遗传学系终身教授

2007年起，美国Emory大学Distinguished The Professor of Human Genetics (杰出讲席教授)

2008年起，华中科技大学基础医学院讲座教授

2010年入选中组部（中国科学院遗传与发育生物学研究所）

李晓江的主要成果有：2008年在世界上首次利用转基因方法建立了非人灵长目的塞缪尔·亨廷顿疾病模型；2015年制备出首例帕金森病的转基因猴模型，并利用CRISPR/Cas9技术制备了首例杜氏肌营养不良症及孤独症猴模型；2018年建立的世界首例亨廷顿基因敲入猪模型的研究成果发表在国际顶级期刊《Cell》杂志，受到国内外的高度好评和关注；研究成果发表于Cell，Nature，Nature Genetics，Nature Medicine，PNAS等国际核心刊物180篇，总影响因子达1388，H指数为63，累计引用率达14221余次。

1．遗传性神经退行性疾病的病理机制研究。

2．细胞内转运与早期神经系统的发育。

Bhat KP, Yan S, Wang CE, Li SH,Li X-J. Differential ubiquitination and degradation of huntingtin fragments modulated by E3 ligase Ube3a. Proc Natl Acad Sci U S A, 2014; published ahead of print March 31, 2014, doi:10.1073/pnas.1402215111

Yang HQ, Wang GH, Sun HT, Shu RZ, Liu T, Wang CE, Liu ZM, Zhao Y, Zhen QY, Yang DS, Huang J, Zhou YL, Li SH, Jiang XD, Xiao ZC,Li X-J*, Lai LX. Species-dependent neuropathology in transgenic SOD1 pigs. Cell Res 2014 Feb 28. doi: 10.1038/铬2014.25. [Epub ahead of print] (*Corresponding author)

Yan S, Wang CE, Wei W, Gaertig MA, Lai L, Li S,Li X-J.TDP-43 causes differentialpathology in neuronal versus glial cells in the mouse brain. Hum 摩尔 Genet. 2014 Jan 10. [Epub ahead of print]

Su Y, Huang SS, Gaertig MA,Li X-J*, Li sh Age-dependent decrease in chaperone activity impairs MANF expression leading to Purkinje cell degeneration in inducible SCA17 鼠科 Neuron,81,349–365 2014 (*Corresponding author)

Xiang JX, Yang H, Zhao T, Sun M, Xu XS, Zhou X.F., Li SH,Li X-J. Hunting锡Associated Protein 1 is essential for postnatal growth by regulating neurogenesis. J Clin Invest. 124(1):85-98. 2014

Xu Q.Q., Huang S.S., Song M.K., Wang C.E. Yan S., Liu X.D., Gaertig M.A., Yu. S.P., Li H., Li S.H.,Li X-J. Synaptic mutant huntingtin inhibits synapsin-1 phosphorylation and causes neurological symptoms. J. 细胞 Biol. 202:1123-1138, 2013.

Weng L, Lin YF, Li AL, Wang CE, Yan S, Sun M, Gaertig MA, Mitha N, Kosaka J, Wakabayashi T, Xu X, Tang B, Li S,Li XJ. Loss of Ahi1 affects early development by impairing BM88/Cend1-mediated neuronal differentiation. J Neurosci. 33:8172-84. 2013.

Cape A, Chen XX, Wang CE, O’Neill A, Lin YF, He J, Xu XS, Yi H, Li H, Li SH,Li X-J. Loss of hunting锡associated protein 1 impairs 胰岛素 secretion from pancreatic beta cells. Cell 摩尔 Life Sci, 69:1305-17. 2012.

Wang H, Huang Z, Huang L, Niu S, Rao X, Xu J, Kong H, Yang J, Yang C, Wu D, Li S,Li XJ, Liu T, Sheng G. Hypothalamic Ahi1 mediates feeding behavior through interaction with 5-HT2C 捕手 J Biol Chem. 287(3):2237-46. 2012

Mandal M, Wei J, Zhong P, Chen J, Duffney LJ, Liu W, Yuen EY, Twelvetrees AE, Li S,Li XJ, Kittler JT, Yan Z. Impaired AMPA receptor trafficking and function by mutant Huntingtin. J Biol Chem. 286:33719-28. 2011.

Huang SS, Ling JJ, Yang S.Li X-J*, Li SH. Neuronal expression of TATA box binding protein containing expanded polylgutamine in knock-in mice reduces chaperone protein response by impairing the 函数 of NF-Y transcription factor. Brain 134(Pt 7):1943-58, 2011 (*Corresponding author)

Havel LS, Wang CE, Huang B, Wade B, Li SH,Li X-J. Preferential localization of N-terminal mutant huntingtin in striatal neurons cause neurological symptoms and is regulated by phosphorylation. Hum 摩尔 獛属 20:1424-37, 2011

Xu XS, Yang H, Lin Y.F., Li X, Cape A, Ressler KJ, Li SH,Li X-J. Neuronal Abelson helper integration site-1 (Ahi1) deficiency in 鼠科 alters TrkB signaling with a depressive phenotype.Proc Natl Acad Sci U S A. 107:19126-31, 2010

Yang DS, Wang CE, Zhao BT, Li W, Quyan Z, Liu ZM, Yang HQ, O’Neill A, Yi H, Li SH,Lai LX,Li X-J. Expression of Huntington disease protein results in apoptotic neurons in the brains of cloned transgenic pigs. Hum. 摩尔 Genet, 19:3983-94, 2010

Lin YF, Xu XS, Cape A, Li SH,Li XJ. Hap1 deficiency in orexin-producing neurons impairs neuronal process extension and leads to abnormal behavior in mICE J Biol Chem. 285:15941-9, 2010.

Bradford J, Shin J-Y, Roberts M, Wang C-E, Sheng G-Q, Li SH, Li X-J. Mutant huntingtin in glial cells exacerbates neurological symptoms of Huntington disease 鼠科 J Biol Chem. 285:10653-61, 2010.

Bradford J, Shin J-Y, Roberts M, Wang C-E,Li X-J, Li SH. Expression of mutant huntingtin in mouse brain astrocytes causes age-dependent neurological symptoms. Proc Natl Acad Sci USA. 106:22480-5,

Friedman MJ, Li S,Li X-J. Activation of gene transcription by heat shock protein 27 may contribute to its neuronal protection. J Biol Chem. 284:27944-51, 2009

Orr AG, Orr AL,Li X-J, Gross RE, Traynelis SF. 腺苷 A2A receptor mediates microglial process retraction. Nature Neurosci. 12:872-8, 2009.

Shah A, Freidman M. Huang SS, Roberts M,Li X-J, Li SH Transcriptional dysregulation of TrkA associates with neurodegeneration in spinocerebellar ataxia type 17. Hum 摩尔 獛属 18: 4141-52, 2009.

Tydlacka S, Wang CE, Wang XJ, Li SH,Li X-J. Differential activities of the ubiquitin-proteasome system in neurons versus glia may account for the preferential accumulation of misfolded proteins in neurons. J. Neurosci. 28: 13285-13295, 2008

Wang CE, Tydlacka S, Adam OL, Yang SH, Graham RK, Hayden MR, Li SH, Chan AW,Li X-J. Accumulation of N-terminal mutant huntingtin in mouse and monkey models implicated as a pathogenic mechanism in Huntington’s disease. Hum. 摩尔. 獛属 17: 2738-2751, 2008

Sheng GQ, Xu XS, Lin YF, Wang CE, Rong J, Peng J, Jiang X, Li SH,Li X-J. Hunting锡associated protein 1 interacts with Ahi1 to regulate cerebellar and 脑干 development in 鼠科 J Clin Invest 118:2785-95, 2008

Wang CE, Zhou H, McGuire JR, Cerullo V, Lee B, Li SH,Li X-J. Suppression of neuropil aggregates and neurological symptoms by an intracellular antibody implicates the cytoplasmic 毒性 of mutant huntingtin. J. 细胞 Biol. 181: 803-816, 2008

Orr AL, Huang SS, Robert MA, Reed JC, Li SH,Li X-J. Sex-dependent effect of BAG1 in ameliorating 摩托车 deficits of huntington’s disease transgenic 鼠科 J. Biol. Chem. 283:16027-36, 2008

Yang SH, Cheng PH, Banta H, Piotrowska-Nitsche K, Yang JJ, Larkin K, Snyder B, Cheng ECH, Liu J, Orkin J, Fang ZH, Smith Y, Bachevalier J, Zola SM, Li SH,Li X-J, Chang AWS. Toward a transgenic model of Huntington’s disease in a non-human 灵长目 Nature 453: 921-924, 2008

Orr AL, Li SH, Wang CE, Li H, Rong J, Xu XS, Mastroberardino PJ, Greenamyre TJ,Li X-J. N-terminal Mutant Huntingtin Associates with Mitochondria Directly and Disrupts the Interaction of Mitochondria with Trafficking Proteins. J. Neurosci. 28: 2783-92, 2008

Wang JJ, Wang CE, Orr A, Tydlacka S, Li SH,Li X-J. Impaired ubiquitin-proteasome system activity in the synapses of Huntington disease mice. J. Cell Biol. 180: 1177-89, 2008.

Friedman MJ, Wang CE,Li XJ, Li SH. Polyglutamine expansion reduces the association of TBP with 脱氧核糖核酸 and induces DNA binding-independent neurotoxicity. J Biol Chem. 283: 8283-90, 2008

Metzger S, Rong J, Nguyen HP, Cape A, Tomiuk J, Soehn A, Propping P, Freudenberg-Hua Y, Freudenberg J, Tong L, Li SH,Li XJ*, Riess O. Hunting锡associated protein-1 is a modifier of the age-at-onset of Huntington's disease. Hum Mol 獛属 17: 1137-46, 2008 (*Corresponding author)

Friedman M., Fang ZH., Shah A., Goursac L., Warren S., Li SH.,Li X-J. Polyglutamine domain regulates the TBP-TFIIB interaction: implications for its normal 函数 and neurodegeneration. Nature 神经科学 10: 1519-28, 2007

李晓江担任的社会职务为：重庆医科大学脑科学与脑疾病研究院学术顾问委员会。